SCIENTIFIC RESULTS

Demonstration through science.

Twelve independent biological studies that objectively demonstrate the high efficacy of Hyperionisation® on the skin, the hallmark of exceptional hospitality.

AT THE HEART OF WELLNESS

A standard of proof, worthy of your establishment.

These studies pursue a precise aim: to assess, under recognised laboratory protocols, what hyperionic water brings to the skin, within the world of spas and prestige hospitality.

They focus on what builds the reputation of a great house: the quality of the skin and the comfort felt by every guest.

For management, they provide a certainty: the elevated experience offered to your clientele rests on results obtained in the laboratory, not on a mere promise.

Hydration, barrier function, skin comfort: what your guests feel, the laboratories have measured.

INDEPENDENT VALIDATION

A commitment to transparency.

Sublio hyperionic water stems from an exceptional technology, developed to the most exacting scientific criteria.

Since its very first installations, Sublio has entrusted the validation of its technology to independent scientific bodies.

Its distinctive characteristics in contact with the skin have been documented by leading independent laboratories.

TWO COMPLEMENTARY APPROACHES

A dual reading, biological and transcriptomic.

It sheds light on the effects of Sublio technology on the skin, far beyond mere sensation.

Ex vivo and in vivo

Studies of the highest calibre

Conducted on ex vivo human skin explants and on human skin in vivo, they measure with laboratory precision the visible effects of hyperionic water on the skin.

Transcriptomics

Transcriptomic analyses

They reveal the variations in expression of specific messenger RNAs after exposure to Sublio hyperionic water, and highlight the finesse of its interaction with the epidermis.

THE STUDIES

Six years of scientific research, one unbroken thread.

Presented from the most recent to the earliest, from 2025 back to 2019, they reveal the full breadth of Sublio’s field of action.

Some protocols rely on demanding laboratory models, such as ex vivo psoriatic skin: they make it possible to measure the skin’s response with precision.

The laboratories’ summary notes are available in French and English.

  • 12independent biological studies
  • 3methods: ex vivo, in vivo, transcriptomics
  • 20volunteers in the in vivo clinical study
  • 2languages available: French and English
122025

Study 12

Clinical study: hydration and barrier function in 20 volunteers

In brief

Hydration and barrier function significantly strengthened, skin redness significantly reduced.

Method
In vivo clinical study, two daily applications over 4 days, mains water and hyperionic mains water
Objective
Measure the effect of hyperionic water on skin hydration and barrier function

Read the summaryFrançaisEnglish

112024

Study 11

Analytical and bacteriological control of a mineral water after Hyperionisation®

In brief

Composition and bacteriological quality strictly unchanged: nothing is added, nothing is removed.

Method
Physico-chemical and bacteriological analyses
Objective
Verify that Sublio alters neither the composition nor the bacteriological quality of the water

Read the summaryFrançaisEnglish

102023

Study 10

Enhancement of a cosmetic active ingredient: retinol

In brief

A markedly more active retinol formulation, with an earlier onset, whether itself hyperionic or preceded by a hyperionic thermal water.

Method
Ex vivo human skin explants, histological analysis at 3 and 6 days
Objective
Assess the effect of Hyperionisation® on the activity of a retinol formulation, applied alone or after a hyperionic thermal water

Read the summaryFrançaisEnglish

092021

Study 09

Hyperionic seawater and mains water: a comparative genomic study

In brief

In both cases, stimulation of the genes associated with skin protection and renewal.

Method
Transcriptomic analysis on ex vivo human skin explants
Objective
Study the compatibility of the Sublio process with waters of very different natures

Read the summaryFrançaisEnglish

082021

Study 08

Hyperionic mains water and thermal water: a comparative genomic study

In brief

Hyperionic thermal water proves more active on the skin than raw thermal water.

Method
Transcriptomic analysis on ex vivo human skin explants
Objective
Compare raw thermal water with hyperionic thermal water

Read the summaryFrançaisEnglish

0706052021

Studies 05, 06 and 07

Assessment on a psoriatic skin model, in three parts

In brief

Reduction of three major markers of psoriatic skin and, significantly, of one inflammatory marker.

Method
Ex vivo psoriatic human skin explants, daily treatment over 4 days
Objective
Assess the effect of hyperionic water on the characteristic markers of psoriatic skin
Read the summaryFrançais050607English050607
042021

Study 04

Skin absorption of trace elements from a hyperionic seawater

In brief

Hyperionic water promotes the skin penetration of beneficial trace elements.

Method
Human skin explants on Franz cells
Objective
Measure the cutaneous bioavailability of minerals

Read the summaryFrançaisEnglish

032021

Study 03

Genomic synthesis across three donors: hyperionic mains water

In brief

Favourable gene response: hydration, regeneration, soothing.

Method
Transcriptomic analysis, three studies combined
Objective
Objectively assess the molecular impact of mains water treated by Sublio

Read the summaryFrançaisEnglish

022021

Study 02

Transcriptomic study: mains water and hyperionic mains water

In brief

Evidence of biological actions involved in hydration, regeneration and skin protection.

Method
Messenger RNA analysis on ex vivo human skin explants
Objective
Identify the genes modulated by exposure to hyperionic water

Read the summaryFrançaisEnglish

012019

Study 01

Hydrating and restorative activity of hyperionic water

In brief

Strengthened skin barrier, enhanced cell cohesion, clearly visible hydration.

Method
Ex vivo human skin explants
Objective
Observe the effect of Hyperionisation® on the skin barrier and cell differentiation

Read the summaryFrançaisEnglish

The documents above are summary notes, written by the laboratories to make their work intelligible to all. The complete study reports, in French and English, can be provided upon request.

A PROVEN INNOVATION

12 independent biological studies.

A patented process, trademarks protected internationally.

World-renowned laboratories behind every result.

Sublio does not make promises,
Sublio demonstrates.